Development and evaluation of a lung-on-a chip device for screening novel antimicrobials
Development and evaluation of a lung-on-a chip device for screening novel antimicrobials
On-going studies by our group have revealed a complex and diverse microbiota in the airways of Cystic fibrosis (CF) patients, which affects disease progression. However, mechanistic studies to determine the … Read More Read More
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Phenotypic & molecular characterization of antimicrobial resistance (AMR) markers; dissemination mechanisms of AMR in bacteria of food-animal origin; whole genome & plasmid sequencing; bioinformatics
Phenotypic & molecular characterization of antimicrobial resistance (AMR) markers; dissemination mechanisms of AMR in bacteria of food-animal origin; whole genome & plasmid sequencing; bioinformatics
Escherichia coli is a genus of bacteria, encountered as an inhabitant of the human and animal gastrointestinal tract. Surveillance is reporting an increase in resistance to all major classes of … Read More Read More
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The microbial ecology of ancient alpine soils
The microbial ecology of ancient alpine soils
Paleosols or “fossil soils” are soils that have not been disturbed by man’s activity for sometimes millions of years. They therefore harbour unique microbial populations that can be studied to … Read More Read More
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Wastewater monitoring for SARS-CoV-2 and other microbial pathogens
Wastewater monitoring for SARS-CoV-2 and other microbial pathogens
As SARS-CoV-2 is shed in high levels in faeces, wastewater testing has become a complementary, early-warning strategy for outbreaks of Covid-19, aiding governmental decision-making around future infection prevention/control policies. Wastewater … Read More Read More
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Synthesis of novel antimicrobials to kill multidrug-resistant bacteria
Synthesis of novel antimicrobials to kill multidrug-resistant bacteria
The continued emergence of antimicrobial resistance is a major global concern. The rapid development of resistance mechanisms by bacteria, as well as the lack of new structurally and mechanistically distinct … Read More Read More
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Exploiting the protein O-glycosylation pathway in opportunistic bacteria as a novel antimicrobial target
Exploiting the protein O-glycosylation pathway in opportunistic bacteria as a novel antimicrobial target
The problem. Antibiotic resistance has become a global health problem of epidemic proportions, especially for infections caused by Gram-negative bacteria. One critical need is to identify novel microbial targets that … Read More Read More
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Disarming antimicrobial responses: how Klebsiella pneumoniae controls inflammasome activation
Disarming antimicrobial responses: how Klebsiella pneumoniae controls inflammasome activation
Microbial infection triggers assembly of inflammasome complexes that promote caspase-1–dependent antimicrobial responses. This project will dissect how the antibiotic resistant pathogen Klebsiella pneumoniae evades inflammasome activation to overcome host restriction … Read More Read More
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AI-Driven Discovery and Characterization of Bacterial Secretion Systems and Their Effectors for Addressing Antimicrobial Resistance
AI-Driven Discovery and Characterization of Bacterial Secretion Systems and Their Effectors for Addressing Antimicrobial Resistance
This project is a 4-year PhD project with enhanced training and 3+ month placement, which is funded by UKRI BBSRC through the NI Landscape Partnership in AI for Bioscience (NILAB) … Read More Read More
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Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials
Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials
This project is a 4-year PhD project with enhanced training and 3+ month placement, which is funded by UKRI BBSRC through the NI Landscape Partnership in AI for Bioscience (NILAB) … Read More Read More
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PhD scholarship in Microbial Ecology and Quorum Sensing – DTU Chemical Engineering
PhD scholarship in Microbial Ecology and Quorum Sensing – DTU Chemical Engineering
The Bioconversions group at DTU Chemical Engineering invites for applications for a position as a PhD candidate with a strong background in the fields of anaerobic biotechnology, microbial ecology, microbial … Read More Read More
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