Rebecca ShepherdNew Drugs for Brain Tumours: Prodrugs of Diazopropyne
New Drugs for Brain Tumours: Prodrugs of Diazopropyne
About the Project The propargyl group, introduced to temozolomide-like drugs for brain tumours by our colleagues in Nottingham, shows considerable pre-clinical promise and is anticipated to be a precursor of … Read More Read More
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Tiara Wang-ArmstrongAnalysing the role of statins in cardiovascular protection
Analysing the role of statins in cardiovascular protection
About the Project Drug-induced cardiovascular toxicity is a major problem affecting a number of cancer chemotherapy drugs (Cross et al., 2015). Due to the increasing number of patients treated by … Read More Read More
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Isabell BakerTargeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer
Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer
About the Project Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an … Read More Read More
Categories:Novel strategy for treatment of chronic wounds via multi-functional liposomal nanocarriers
Novel strategy for treatment of chronic wounds via multi-functional liposomal nanocarriers
About the Project A confounding issue of non-healing skin wounds is the presence of pathogenic bacteria, that protect themselves from conventional antibiotic treatments by encasing themselves within protective shields (biofilms). … Read More Read More
Categories:ERK5 MAPK signalling in Alzheimer’s disease
ERK5 MAPK signalling in Alzheimer’s disease
About the Project Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. This is particularly true for Alzheimer’s disease, which is multifactorial and … Read More Read More
Categories:Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
About the Project Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up … Read More Read More
Categories:Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives
Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives
About the Project Diseases affecting the bowel such as colorectal cancer (CRC) and the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease are major global healthcare challenges in the … Read More Read More
Categories:Development of antibody-drug conjugates (ADCs) for oncology indications
Development of antibody-drug conjugates (ADCs) for oncology indications
About the Project A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. A promising way to … Read More Read More
Categories:Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
About the Project Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. There is currently no cure for this disease. … Read More Read More
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Antonio SanchezDevelopment of rapid assays for pathogen detection and antimicrobial susceptibility testing.
Development of rapid assays for pathogen detection and antimicrobial susceptibility testing.
About the Project This fully funded PhD position is available to start in September 2024 for a highly motivated candidate to contribute to our ongoing research program focusing on the … Read More Read More
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