Rebecca Shepherd4-year PhD Studentship: Automating Literature Mining and Triangulation with Large Language Models and Knowledge Graphs
4-year PhD Studentship: Automating Literature Mining and Triangulation with Large Language Models and Knowledge Graphs
About the Project Around 1.7 million new articles were published in PubMed in 2022, with a further 47,000 pre-prints posted on bioRxiv and medRxiv in the same period. Some of … Read More Read More
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Sergio DiazQuantifying prognosis in the current era of antiretroviral therapy among persons with HIV in Europe and North America across different HIV acquisition route groups
Quantifying prognosis in the current era of antiretroviral therapy among persons with HIV in Europe and North America across different HIV acquisition route groups
About the Project In Europe and North America, prognosis for persons with HIV (PWHIV) has improved since the introduction of combined antiretroviral in 1996[1]. There has been considerable research into … Read More Read More
Categories:Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
About the Project Parkinson’s disease is a progressive neurodegenerative disorder characterised by a wide range of motor and non-motor features, for which there is no known cause. There is large … Read More Read More
Categories:Metabolomic characterisation of adiposity across the life course
Metabolomic characterisation of adiposity across the life course
About the Project There is evidence that adiposity, measured by body mass index (BMI), causally influences a range of health outcomes, but little understanding of the mechanisms driving BMI effects. … Read More Read More
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Zoey MartinezA methodological framework for incorporating multiple outcomes into hybrid implementation and effectiveness trials
A methodological framework for incorporating multiple outcomes into hybrid implementation and effectiveness trials
About the Project Background to the project Many policies are adopted into practice without a solid evidence. Rigorous randomised trials are therefore needed to inform decisions about the implementation of … Read More Read More
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William MielcarekInvestigating statistical methods to assess the conduct and integrity of clinical trials
Investigating statistical methods to assess the conduct and integrity of clinical trials
About the Project Background to the project There is evidence to suggest that a substantial quantity of fabricated clinical trials are in circulation. Forensic analysis of all RCTs submitted to … Read More Read More
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Allison WilburPilot and feasibility studies for online clinical trials
Pilot and feasibility studies for online clinical trials
About the Project Background to the project Prior to conducting a clinical trial there may be uncertainty around aspects of the design (Lancaster, J Eval Clin Pract. 2004;10(2):307-12). Uncertainties should … Read More Read More
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Mark MillerImproving Design and Analysis of Non-Inferiority Trials with sparse outcome data
Improving Design and Analysis of Non-Inferiority Trials with sparse outcome data
About the Project Background to the project Novel interventions are often developed with the aim to achieve similar effectiveness to existing ones, with additional advantages in terms of reduced toxicity, … Read More Read More
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Elham PourbakhshIdentifying and validating digital biomarkers of frailty in Parkinson’s disease
Identifying and validating digital biomarkers of frailty in Parkinson’s disease
About the Project Background Frailty is a medical syndrome of physiological decline, accompanied by diminished resistance to stressors. It is common (prevalence approximately 40%) and under-recognised in Parkinson’s disease (PD), … Read More Read More
Categories:Data linkage and analysis without a unique identifier in clinical trials.
Data linkage and analysis without a unique identifier in clinical trials.
About the Project Background to the project Conducting pragmatic trials and utilising routinely collected data in clinical trials is becoming more common. Usually, a unique identifier (for example NHS number) … Read More Read More
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