Daisy LyHigh throughput exploration of the design space for antifungal nanocarrier development
High throughput exploration of the design space for antifungal nanocarrier development
About the Project Fungal and bacterial infections contribute to over 7 million deaths yearly, affecting over 300 million people globally ( GAFFI ). Since many antimicrobial drugs are ancient, we … Read More Read More
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Rebecca ShepherdNew Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
About the Project The imidazotetrazine ring system that forms the core of the anticancer drug temozolomide is a fascinating prodrug delivery device. The bicyclic structure bears only three substituents. These … Read More Read More
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Antonio SanchezAnalysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
About the Project Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to … Read More Read More
Categories:Synthetic Protein-Transporters for Enhanced Transduction Activity
Synthetic Protein-Transporters for Enhanced Transduction Activity
About the Project Intracellular protein delivery is key to probing important cellular processes and developing advanced biotherapeutics. However, protein trafficking into the cell, and more specifically to the cytosol remains … Read More Read More
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Jim TaylorPBPK modelling of disease-drug interactions using transporter and enzyme biomarker data
PBPK modelling of disease-drug interactions using transporter and enzyme biomarker data
About the Project Precision dosing strategies require accounting for between-patient variability in pharmacokinetics. To that end, significant progress has been made in identifying and evaluating endogenous biomarkers of transporter function, … Read More Read More
Categories:New Drugs for Brain Tumours: A Locoregional Implant Brain Tumours
New Drugs for Brain Tumours: A Locoregional Implant Brain Tumours
About the Project Next-generation temozolomide derivatives for the treatment of high-grade glioma have been developed at the University of Bradford. This project will optimise an implantable formulation to be deposited … Read More Read More
Categories:Freeze-dried bacteriophage formulations against antibiotic-resistant bacteria
Freeze-dried bacteriophage formulations against antibiotic-resistant bacteria
About the Project Antimicrobial resistance (AMR) presents a significant global public health issue. According to a recent publication in The Lancet , there were an estimated 5 million deaths associated … Read More Read More
Categories:Designing and evaluating novel nanotherapeutics to enhance the effectiveness of radiotherapy in the treatment of solid cancers.
Designing and evaluating novel nanotherapeutics to enhance the effectiveness of radiotherapy in the treatment of solid cancers.
About the Project One in two cancer patients will receive radiotherapy as part of their treatment. For patients with a localised cancer diagnosis effective radiotherapy represents the best chance of … Read More Read More
Categories:Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy
Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy
About the Project Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still … Read More Read More
Categories:Peptide-based nanoparticles for brain targeted gene delivery.
Peptide-based nanoparticles for brain targeted gene delivery.
About the Project Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain … Read More Read More
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