Varsha MeyersMolecular switches
Molecular switches
About the Project Research activities in Kilian group are centred on the design and synthesis of novel organophosphorus and heavier Group 15 (As, Sb, Bi) organoelement compounds. We synthesize new … Read More Read More
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Aly HillDeveloping the next generation of broad-spectrum antiviral polymers
Developing the next generation of broad-spectrum antiviral polymers
About the Project Applications are invited for a funded PhD position in the School of Chemistry at the University of Birmingham. The School of Chemistry is keen to achieve a … Read More Read More
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Niels MadsenStereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates: Application to a Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Stereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates: Application to a Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
About the Project Background A long-standing fundamental challenge in cross-coupling chemistry is the formation of stereodefined carbon-carbon bonds using Csp3-Csp2 Suzuki-Miyaura cross-coupling. Secondary, enantiopure alkyl boron reagents are readily accessible, … Read More Read More
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Artur GevorgyanPhD in Chemistry - Taking Crystal Sponges into the Nanoscale Using 3D Electron Diffraction
PhD in Chemistry - Taking Crystal Sponges into the Nanoscale Using 3D Electron Diffraction
About the Project Bright, highly motivated candidates are invited to apply for a fully funded 3.5 year PhD position in the School of Chemistry, available to commence on 1st October … Read More Read More
Categories:Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
About the Project Background: Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the current COVID-19 pandemic. Notwithstanding progress in available vaccines for COVID-19, there remains a need … Read More Read More
Categories:Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
About the Project Background: Fragment-based methods are established for the identification of lead compounds in drug discovery.[1] Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins. However, … Read More Read More
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Julian NavarroChemically Modified Therapeutic Nucleic Acids for Neurological Diseases
Chemically Modified Therapeutic Nucleic Acids for Neurological Diseases
About the Project Supervisory Team: Afaf El-Sagheer and Matthias Baud Project description Therapeutic oligonucleotides are unique in targeting mRNA particularly those that cannot be addressed by conventional small molecule drugs … Read More Read More
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Mary DelongLanthanide(II) Hydrides for Nitrogen Fixation and Ammonia Production
Lanthanide(II) Hydrides for Nitrogen Fixation and Ammonia Production
About the Project Research summary When we think of fossil fuel products we often think of petrol, oils, and plastics. But do you think about kai? Half of global food … Read More Read More
Categories:Synthesis of macrocycles and medium-sized rings via new ring expansion approaches
Synthesis of macrocycles and medium-sized rings via new ring expansion approaches
About the Project Summary Macrocycles (12+ membered rings) and medium-sized rings (8–11-membered) are cyclic molecules with great potential in many scientific fields and technologies – especially in medicinal chemistry. However, … Read More Read More
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Alejandro FernandezBond Activation with Main Group Bimetallic Bonds
Bond Activation with Main Group Bimetallic Bonds
About the Project A PhD studentship is available in the group of Dr Stephanie Urwin (School of Chemistry, The University of Edinburgh; https://www.chem.ed.ac.uk/staff/academic-staff/dr-stephanie-j-urwin Project Summary Many catalysts feature rare elements … Read More Read More
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