Tiffany WilliamsCryo-EM study of the human kinetochore
Cryo-EM study of the human kinetochore
About the Project Our research is focused on understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome segregation ensures that both daughter cells … Read More Read More
Categories:Discovering the “missing” transcription mechanisms
Discovering the “missing” transcription mechanisms
About the Project The complexity of eukaryotic life forms is driven by RNA polymerase II (Pol II), which transcribes all protein-coding genes and thousands of non-coding RNA loci. In vivo … Read More Read More
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Rodrigo OsorioStructural study of spliceosomes stalled by antitumor compounds
Structural study of spliceosomes stalled by antitumor compounds
About the Project Splicing is a critical step in gene expression, responsible for removing non-coding introns from pre-mRNA transcripts. This process can occur in alternative ways, enabling the production of … Read More Read More
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Elham PourbakhshInvestigating the role of AMPK in endothelial cell function
Investigating the role of AMPK in endothelial cell function
About the Project AMP-activated protein kinase (AMPK) plays an important role in maintaining energy homeostasis at both the cellular and whole body level 1 . Dysregulated metabolism underlies many diseases … Read More Read More
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Antonio SanchezChina Scholarship Council: Elucidating the energetics that govern the dynamic instability of microtubules
China Scholarship Council: Elucidating the energetics that govern the dynamic instability of microtubules
About the Project Microtubules are mesoscale filaments built from αβ- tubulin dimers that form part of the cell cytoskeleton. Microtubules drive the segregation of genetic material, form the tracks for … Read More Read More
Categories:China Scholarship Council: Cryo electron microscopy of the exocyst complex on membranes
China Scholarship Council: Cryo electron microscopy of the exocyst complex on membranes
About the Project Cell communication requires both a sending and a receiving cell. To send messages, Metazoan harness trafficking machinery. Yet, despite basic knowledge of the components and regulatory factors … Read More Read More
Categories:Biological insights from the analysis of protein conformational variability (HAYWARDS_U25SCI)
Biological insights from the analysis of protein conformational variability (HAYWARDS_U25SCI)
About the Project Primary Supervisor - Prof. Steven Hayward Proteins are very flexible molecules, changing their shape or conformation to function. In the past, this dynamic aspect of protein function … Read More Read More
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