Leandro OliveiraDevelopment of nano-formulation strategies to enhance the therapeutic potential of host defence peptides for the treatment of inflammatory bowel disease (Project ID SAS0208)
Development of nano-formulation strategies to enhance the therapeutic potential of host defence peptides for the treatment of inflammatory bowel disease (Project ID SAS0208)
About the Project A fully funded 3-year PhD studentship is available for drug discovery research on Host Defence Peptides (HDPs) at Edinburgh Napier University (ENU). This multidisciplinary project is a … Read More Read More
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Farrukh Ali KhanExperimental and Computational Modelling Studies to Enhance the Performance of Dry Powder Inhalers for the Management of Asthma and COPD
Experimental and Computational Modelling Studies to Enhance the Performance of Dry Powder Inhalers for the Management of Asthma and COPD
About the Project Inhaled medications delivered via dry powder inhalers (DPIs) can help to relief symptoms for those suffering from health conditions that affect the lungs, such as asthma and … Read More Read More
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Daisy LyEnzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants
Enzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants
About the Project One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often … Read More Read More
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Niels MadsenStereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates: Application to a Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Stereospecific Csp3-Csp2 Cross-Coupling of Saturated Heterocyclic Boronates: Application to a Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
About the Project Background A long-standing fundamental challenge in cross-coupling chemistry is the formation of stereodefined carbon-carbon bonds using Csp3-Csp2 Suzuki-Miyaura cross-coupling. Secondary, enantiopure alkyl boron reagents are readily accessible, … Read More Read More
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Rebecca ShepherdNew Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
About the Project The imidazotetrazine ring system that forms the core of the anticancer drug temozolomide is a fascinating prodrug delivery device. The bicyclic structure bears only three substituents. These … Read More Read More
Categories:Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
About the Project Background: Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the current COVID-19 pandemic. Notwithstanding progress in available vaccines for COVID-19, there remains a need … Read More Read More
Categories:Synthetic Protein-Transporters for Enhanced Transduction Activity
Synthetic Protein-Transporters for Enhanced Transduction Activity
About the Project Intracellular protein delivery is key to probing important cellular processes and developing advanced biotherapeutics. However, protein trafficking into the cell, and more specifically to the cytosol remains … Read More Read More
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Aly HillDeveloping Enabling Synthetic Methods for Accelerated Peptidomimetic Drug Discovery
Developing Enabling Synthetic Methods for Accelerated Peptidomimetic Drug Discovery
About the Project Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with … Read More Read More
Categories:Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
Modular Synthetic Platform for the Optimisation of Fragment Hits to 3-D Lead Compounds for Medicinal Chemistry
About the Project Background: Fragment-based methods are established for the identification of lead compounds in drug discovery.[1] Fragments are small molecules (molecular weight ~150-300) which bind weakly to proteins. However, … Read More Read More
Categories:Freeze-dried bacteriophage formulations against antibiotic-resistant bacteria
Freeze-dried bacteriophage formulations against antibiotic-resistant bacteria
About the Project Antimicrobial resistance (AMR) presents a significant global public health issue. According to a recent publication in The Lancet , there were an estimated 5 million deaths associated … Read More Read More
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