Rebecca ShepherdExploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer
Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer
About the Project Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with … Read More Read More
Categories:4-year PhD Studentship: Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury
4-year PhD Studentship: Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury
About the Project Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific … Read More Read More
Categories:
Jim TaylorGene-based replacement therapy for hearing loss
Gene-based replacement therapy for hearing loss
About the Project Hearing loss is the most common sensory dysfunction in humans, and it is associated with social isolation and depression. Approximately 1 billion people in the world will … Read More Read More
Categories:
Jing(静) WangInvestigating lysosomal (dys)function in ageing and neurodegeneration
Investigating lysosomal (dys)function in ageing and neurodegeneration
About the Project Project Overview: Ageing is associated with a decline in the functions of an organism (López-Otín, C. e t al. Cell , 2023) and correlates with an increased … Read More Read More
Categories:
Mary DelongUse it or lose it: what determines the regulation mode of a given gene?
Use it or lose it: what determines the regulation mode of a given gene?
About the Project All organisms must tightly control gene expression. In bacteria, gene regulation is mediated by either an activator or a repressor which binds DNA to turn a gene … Read More Read More
Categories:Exploring Molecular Pathways for Improved Neural Regeneration in Spinal Cord Injury
Exploring Molecular Pathways for Improved Neural Regeneration in Spinal Cord Injury
About the Project In the UK, 50,000 people currently live with spinal cord injury (SCI), and an additional 2,500 new cases are reported annually. SCI results in a permanent loss … Read More Read More
Categories:Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis
Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis
About the Project Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Only around 60% respond to … Read More Read More
Categories:
Kris ReensGenomic and Proteomics-Based Characterisation of Microalgal Cell Factories
Genomic and Proteomics-Based Characterisation of Microalgal Cell Factories
About the Project Microalgae have generated increasing interest as microbial cell factories to produce proteins, pigments, therapeutics, and nutraceuticals. This is because they are solar-powered and can fix CO 2 … Read More Read More
Categories:Glycosylation in Microalgal Host Cells
Glycosylation in Microalgal Host Cells
About the Project Microalgae have generated increasing interest as microbial cell factories to produce therapeutics proteins. This is because they can grow on very cheap media and their GRAS (generally … Read More Read More
Categories:
Alejandro CostaUnderstanding the role of spliceosome gene mutations in disease
Understanding the role of spliceosome gene mutations in disease
About the Project The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained … Read More Read More
Categories: