Tiffany WilliamsHow does TRIM21 degrade diverse substrates from viruses to neurodegenerative aggregates?
How does TRIM21 degrade diverse substrates from viruses to neurodegenerative aggregates?
About the Project TRIM21 is the cytosolic E3 ligase and antibody receptor responsible for intracellular antibody immunity. Unlike other ubiquitin ligases, TRIM21 doesn’t have a defined substrate but is directed … Read More Read More
Categories:
Rodrigo OsorioGreen electrospun nanofiber membranes for water treatment
Green electrospun nanofiber membranes for water treatment
About the Project Access to clean drinking water and sanitation has seen substantial progress in recent time, however there is still a large part of the global population, that live … Read More Read More
Categories:
Niels MadsenThe cycling of climate-active sulfur compounds by major crops (TODD_UBIO25ARIES)
The cycling of climate-active sulfur compounds by major crops (TODD_UBIO25ARIES)
About the Project Scientific background: Dimethylsulfoniopropionate (DMSP) is known as a marine anti-stress compound made by algae and bacteria. It has key roles in global nutrient and sulfur cycling, signalling, … Read More Read More
Categories:
Amalie JohannsenAntibiotic discovery in Streptomyces bacteria (HUTCHINGS_J25DTP1)
Antibiotic discovery in Streptomyces bacteria (HUTCHINGS_J25DTP1)
About the Project The continued evolution of antimicrobial resistance (AMR) in pathogenic bacteria represents a significant threat to global health and new antibiotics with novel mechanisms of action are urgently … Read More Read More
Categories:Relieving glucose-mediated carbon catabolite repression to engineer antibiotic over production in Streptomyces species. (HUTCHINGS_J25DTP2)
Relieving glucose-mediated carbon catabolite repression to engineer antibiotic over production in Streptomyces species. (HUTCHINGS_J25DTP2)
About the Project Streptomyces is the largest genus of bacteria, well studied because it makes molecules called specialised metabolites that form the basis of 55% of antibiotics as well as … Read More Read More
Categories:Taming the Viral Wolf: Cracking the Code of Gene Transfer Agents in Bacteria (LE_J25DTP)
Taming the Viral Wolf: Cracking the Code of Gene Transfer Agents in Bacteria (LE_J25DTP)
About the Project Bacteria commonly exchange genetic information (DNA) in a process called horizontal gene transfer as they evolve and adapt to changes in their local environment. Understanding horizontal gene … Read More Read More
Categories:How do plasmid-borne regulatory genes influence bacterial behaviour in complex communities? (MALONE_J25DTP)
How do plasmid-borne regulatory genes influence bacterial behaviour in complex communities? (MALONE_J25DTP)
About the Project Conjugative plasmids play a crucial role in bacterial evolution as drivers of horizontal gene transfer (HGT) and as a source of new genetic information. This project will … Read More Read More
Categories:Transcribing Success: Characterising the Factor Behind Bacterial Development and Antibiotic Production (SCHLIMPERT_J25DTP)
Transcribing Success: Characterising the Factor Behind Bacterial Development and Antibiotic Production (SCHLIMPERT_J25DTP)
About the Project Over 50% of the antibiotics used in medicine are produced by Streptomyces bacteria. The production of antibiotics is intertwined with the Streptomyces lifecycle and controlled by diverse … Read More Read More
Categories:Targeting Pseudomonas aeruginosa virulence factors (WILKINSON_J25DTP2)
Targeting Pseudomonas aeruginosa virulence factors (WILKINSON_J25DTP2)
About the Project The emergence of multi-drug antibiotic resistance in many disease-causing bacteria (pathogens) has raised the prospect of a devastating return to the pre-antibiotic era, and, as was highlighted … Read More Read More
Categories:
Artur GevorgyanBiodegradable platforms for co-delivery of inorganic and organic antibiotics to tackle AMR bacteria
Biodegradable platforms for co-delivery of inorganic and organic antibiotics to tackle AMR bacteria
About the Project This PhD opportunity will be based at Heriot-Watt University, Edinburgh. Please contact Dr Humphrey Yiu ( h.h.yiu@hw.ac.uk ) for further details. Antimicrobial resistance (AMR) is a global … Read More Read More
Categories: