How membrane proteins are regulated - revealing the dynamic S-acyl proteome in plants
How membrane proteins are regulated - revealing the dynamic S-acyl proteome in plants
About the Project S-acylation involves addition of fatty acids to sulfhydryl groups of cysteine residues within proteins, typically altering protein function by changing behaviour within cellular membranes. S-acylation is highly … Read More Read More
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Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
About the Project Amyotrophic lateral sclerosis (ALS)—the commonest type of motor neuron disease (MND)—is a rapidly progressive paralysing illness of mid-adulthood. It has a lifetime risk of ~1 in 400, … Read More Read More
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Development of new molecular therapies to treat motor neuron disease (MND)
Development of new molecular therapies to treat motor neuron disease (MND)
About the Project The battle against Motor Neuron Disease (MND) is entering an exciting phase with the development of gene therapies aimed at reducing pathogenic proteins. Our team has developed … Read More Read More
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Exploring mechanisms underlying viral infections in initiating pulmonary fibrosis
Exploring mechanisms underlying viral infections in initiating pulmonary fibrosis
About the Project Respiratory viral infections are the most prevalent illnesses in humans. In addition to their immediate health effects, these infections can result in long-term lung conditions like pulmonary … Read More Read More
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Targeting transposable elements in cancer
Targeting transposable elements in cancer
About the Project Transposable elements (TEs), also known as “jumping genes” are repetitive genomic elements that represent almost half of the human genome. TEs harbour regulatory elements and transcription factor … Read More Read More
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Understanding the mechanisms of crossover recombination control
Understanding the mechanisms of crossover recombination control
About the Project Brief summary The project aims to gain further mechanistic insight into meiotic crossover formation in plants. Importance of Research Crossover recombination underlies genetic diversity, evolution and crop … Read More Read More
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Investigating abnormal calcium release as a cause of sudden cardiac death in inherited heart disease
Investigating abnormal calcium release as a cause of sudden cardiac death in inherited heart disease
About the Project Sudden cardiac death resulting from disturbances in heart rhythm is a major cause of death globally. It is known that the structure and function of heart muscle … Read More Read More
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Molecular Mechanisms of Receptors in Inflammation and Pain
Molecular Mechanisms of Receptors in Inflammation and Pain
About the Project Are you interested in understanding how the cardiovascular and nervous systems work? Join our research team to study the molecular mechanisms that regulate receptors and their signaling … Read More Read More
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How do RNA-binding proteins control splice site selection? A multi-disciplinary approach
How do RNA-binding proteins control splice site selection? A multi-disciplinary approach
About the Project Almost every protein-coding gene in vertebrates can and does express multiple proteins. This is achieved primarily by RNA splicing, which is an essential step in gene expression … Read More Read More
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Lymphatic Function in Inflammation
Lymphatic Function in Inflammation
About the Project We are seeking a highly motivated student with a strong academic record (high GPA) and preferably a background in physiology, biomedical science, immunology, or related fields. Knowledge … Read More Read More
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