Antonio SanchezAnalysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
About the Project Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to … Read More Read More
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Daisy LyInvestigating proinflammatory and toxicological properties of nano-microparticles (NMP) from different sources of plastic waste and environmental pollution
Investigating proinflammatory and toxicological properties of nano-microparticles (NMP) from different sources of plastic waste and environmental pollution
About the Project Research Group Biomedical Research Group Proposed supervisory team Dr Grisha Pirianov Dr Dannielle Green Theme Biomedicine and Environmental Pollution Summary of the research project Background: Plastic production … Read More Read More
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Tiara Wang-ArmstrongAnalysing the role of statins in cardiovascular protection
Analysing the role of statins in cardiovascular protection
About the Project Drug-induced cardiovascular toxicity is a major problem affecting a number of cancer chemotherapy drugs (Cross et al., 2015). Due to the increasing number of patients treated by … Read More Read More
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Isabell BakerTargeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer
Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer
About the Project Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an … Read More Read More
Categories:Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
About the Project Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up … Read More Read More
Categories:Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
About the Project Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. There is currently no cure for this disease. … Read More Read More
Categories:MRC DiMeN Doctoral Training Partnership: Cracking the Mitochondrial Code: New Frontiers in Tackling Linezolid Toxicity for Multi-Drug Resistant Tuberculosis
MRC DiMeN Doctoral Training Partnership: Cracking the Mitochondrial Code: New Frontiers in Tackling Linezolid Toxicity for Multi-Drug Resistant Tuberculosis
About the Project We invite applications for a fully funded PhD studentship to explore the role of mitochondrial DNA (mtDNA) in adverse drug reactions (ADRs) to linezolid, a key drug … Read More Read More
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