Rishikesh GuptaAlterations in reparative dentinogenesis with ageing, gender and genetic predisposition
Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition
About the Project Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of … Read More Read More
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Luke McCoyPhD in stem cell modelling for neuropsychiatric disorders
PhD in stem cell modelling for neuropsychiatric disorders
About the Project This project provides a unique opportunity to explore the developmental origins of schizophrenia—a severe mental health disorder—using cutting-edge patient-derived stem cell models. By generating both 2D and … Read More Read More
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Yana KarapetyanAssessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes
Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes
About the Project A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer … Read More Read More
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Tiffany WilliamsUsing human organoids to unravel epigenetic mechanisms in health and Inflammatory Bowel Diseases
Using human organoids to unravel epigenetic mechanisms in health and Inflammatory Bowel Diseases
About the Project Project Overview The intestinal epithelium provides a critical barrier that contributes towards the establishment of a finely tuned homeostasis in the human gut. Development of a fully … Read More Read More
Categories:Mechanisms regulating blood stem cell self-renewal and differentiation
Mechanisms regulating blood stem cell self-renewal and differentiation
About the Project Project Overview The Wilkinson research group focuses on the biology and translational applications of blood-forming haematopoietic stem cells (HSCs). Self-renewing multipotent HSCs are a rare but incredibly … Read More Read More
Categories:Therapeutic vulnerabilities of TET2-mutant clonal haematopoiesis
Therapeutic vulnerabilities of TET2-mutant clonal haematopoiesis
About the Project Project Overview Clonal haematopoiesis (CH), the clonal expansion of a haematopoietic stem cell (HSC) and its progeny driven by somatic mutations, is the shared pre-clinical ancestor of … Read More Read More
Categories:Cancer-associated sensitisation mechanisms to selective RNA methyltransferase inhibition
Cancer-associated sensitisation mechanisms to selective RNA methyltransferase inhibition
About the Project Project Overview Epitranscriptomics, the modulation of RNA function via its chemical modification, has emerged as a pervasive new mechanism of gene regulation. The role of the epitranscriptome … Read More Read More
Categories:Multiomics to decipher T cell development in the thymus
Multiomics to decipher T cell development in the thymus
About the Project Project Overview Ongoing projects in the Teichmann team are generating scRNA-seq and chromatin accessibility profiles of thymic cells using the 10X multiome kit, combined with multiplex protein … Read More Read More
Categories:Unravelling The Parallels Between Regeneration & Tumorigenesis
Unravelling The Parallels Between Regeneration & Tumorigenesis
About the Project Project Overview Some organisms, such as salamanders, retain a remarkable capacity for regeneration in various organs, which occurs through the process of epimorphic regeneration. In mammals, however, … Read More Read More
Categories:Patient outcomes and new therapies in aortic aneurysm using iPSC ‘disease-in-a-dish’ models
Patient outcomes and new therapies in aortic aneurysm using iPSC ‘disease-in-a-dish’ models
About the Project Project Overview We have pioneered the use of induced pluripotent stem cells from patients with genetically mediated aortic aneurysms (such as Marfan and Loeys-Dietz syndromes) to set … Read More Read More
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