Rebecca ShepherdSynBac: Synthetic Baculovirus Genomes for Next-generation Druf Discovery and Gene Therapy
SynBac: Synthetic Baculovirus Genomes for Next-generation Druf Discovery and Gene Therapy
About the Project Baculovirus is a highly efficient delivery system for recombinant genes into eukaryotic cells, with great impact on the production of eukaryotic proteins, including high-value drug targets for … Read More Read More
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Jing(静) WangInvestigating lysosomal (dys)function in ageing and neurodegeneration
Investigating lysosomal (dys)function in ageing and neurodegeneration
About the Project Project Overview: Ageing is associated with a decline in the functions of an organism (López-Otín, C. e t al. Cell , 2023) and correlates with an increased … Read More Read More
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Mary DelongExploring Molecular Pathways for Improved Neural Regeneration in Spinal Cord Injury
Exploring Molecular Pathways for Improved Neural Regeneration in Spinal Cord Injury
About the Project In the UK, 50,000 people currently live with spinal cord injury (SCI), and an additional 2,500 new cases are reported annually. SCI results in a permanent loss … Read More Read More
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Anges SheltonInvestigating Dietary Approaches to Improve Muscle Health
Investigating Dietary Approaches to Improve Muscle Health
About the Project The maintenance of good muscles health provides a key aspect of general health. Reduced muscle health is associated with both ageing and a range of diseases. In … Read More Read More
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Tiffany WilliamsRNA therapy development for inherited eye diseases
RNA therapy development for inherited eye diseases
About the Project Applications are welcomed for self-funded students to pursue a PhD in RNA therapeutics. The PhD project will use short activating RNAs to specifically increase target gene expression … Read More Read More
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Rodrigo OsorioEnabling novel E3 ligases for targeted protein degradation therapeutics.
Enabling novel E3 ligases for targeted protein degradation therapeutics.
About the Project Targeted protein degradation (TPD) has transformed cancer drug discovery by enabling removal of harmful proteins using small molecule degraders. PROTACs (Proteolysis Targeting Chimeras) and MGDs (Molecular Glue … Read More Read More
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Zoey MartinezEnzymes for Sustainable Amide Synthesis Under Aqueous Conditions for Pharmaceutical Applications
Enzymes for Sustainable Amide Synthesis Under Aqueous Conditions for Pharmaceutical Applications
About the Project A PhD studentship is available to work on a multidisciplinary project led by Professor Andrew Carnell on the discovery and development of enzymes for application in the … Read More Read More
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Elham PourbakhshEpigenome engineering: priming chromatin for pathogen resistance
Epigenome engineering: priming chromatin for pathogen resistance
About the Project Brief Plants can become more resilient to pathogen challenge after priming treatments, which is associated with changes to chromatin. This project uses epigenome engineering to re-sculpt chromatin … Read More Read More
Categories:Non-genetic mechanisms of resistance to cell cycle inhibitors in cancer
Non-genetic mechanisms of resistance to cell cycle inhibitors in cancer
About the Project Targeting cell cycle regulation is proving increasingly effective in cancer treatment. CDK4/6 inhibitors, including Palbociclib, Ribociclib and Abemaciclib, are used to treat metastatic ER+, HER2- metastatic breast … Read More Read More
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Aly AndrewsEngineering stable designer chromosomes (NIEDUSZYNSKI_E25DTP2)
Engineering stable designer chromosomes (NIEDUSZYNSKI_E25DTP2)
About the Project Recent technological advances allow us to write and build whole chromosomes, allowing unprecedented potential for the design and creation of cellular machines. Synthetic designer de novo chromosomes … Read More Read More
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