Obtaining an integrated understanding of oncogenic RAS signalling
Obtaining an integrated understanding of oncogenic RAS signalling
About the Project The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of … Read More Read More
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Understanding the transcription factor network governing blood stem cell expansion
Understanding the transcription factor network governing blood stem cell expansion
About the Project Recent advances in blood stem cell expansion outside the body have afforded us an unprecedented opportunity to unravel the molecular regulators that allow a stem cell to … Read More Read More
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Polysialyltransferases as a target in metastatic cancer
Polysialyltransferases as a target in metastatic cancer
About the Project Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Polysialic acid … Read More Read More
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
About the Project Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. … Read More Read More
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Ion channel signalling in cancer cells
Ion channel signalling in cancer cells
About the Project Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to … Read More Read More
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The Xu lab at Georgia State University - Fully funded position available
The Xu lab at Georgia State University - Fully funded position available
About the Project The Xu lab focuses on Nanobodies. Nanobodies are antigen-binding entities derived from the heavy chain-only antibodies of camelid animals, and they retain full antigen specificity at a … Read More Read More
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Nano-scale measurement and manipulation of heat for healthcare
Nano-scale measurement and manipulation of heat for healthcare
About the Project Background The ability to measure and manipulate heat is fundamental when studying biological processes, chemical reactions and even fundamental physics. By changing temperature, biological, chemical and physical … Read More Read More
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Molecular Mechanisms of Cancer Progression
Molecular Mechanisms of Cancer Progression
About the Project The Wells Invasion and Metastasis Research Group is interested in how cancer cells are able to dissociate from the primary tumour, invade the surrounding tissue and subsequently … Read More Read More
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A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer
A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer
About the Project This is one of two new fully funded PhD studentships in the Institute of Cancer Therapeutics Doctoral Training Centre (ICT-DTC) at the University of Bradford. Focused on … Read More Read More
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Dynamics of the peri-nuclear actomyosin network for correct chromosome positioning in early mitosis
Dynamics of the peri-nuclear actomyosin network for correct chromosome positioning in early mitosis
About the Project To maintain genetic integrity, human cells must inherit the whole set of chromosomes without any loss or excess when the cell division takes place. To ensure this … Read More Read More
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