Alfred MiradaExploiting Deep Learning-based protein structure prediction for function annotation and structural biology
Exploiting Deep Learning-based protein structure prediction for function annotation and structural biology
About the Project Applications will be reviewed until a suitable candidate is appointed. Protein structural information is crucial for an understanding of protein function and evolution. Currently, only there is … Read More Read More
Categories:
Amalie JohannsenStructural insights into genome control by cohesin
Structural insights into genome control by cohesin
About the Project Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a … Read More Read More
Categories:
Helen Jacobs-LewissDelivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM
Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM
About the Project The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Targeting OMP biogenesis … Read More Read More
Categories:How does myosin 10 contribute to filopodia formation and stability?
How does myosin 10 contribute to filopodia formation and stability?
About the Project How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through … Read More Read More
Categories:
Alejandro CostaAdvanced Electron Paramagnetic Resonance (EPR) spectroscopy – method development and applications
Advanced Electron Paramagnetic Resonance (EPR) spectroscopy – method development and applications
About the Project Electron Paramagnetic Resonance (EPR) spectroscopy is a magnetic resonance technique that is exclusively and exquisitely sensitive to unpaired electrons that are found in radicals and paramagnetic metal … Read More Read More
Categories:
Isabell BakerSex differences in epicardial fat modulation of cardiac function
Sex differences in epicardial fat modulation of cardiac function
About the Project This project will aim to determine whether structural and physiological properties of epicardial adipose tissue are responsible for the sex differences in human myocardial function and cardiac … Read More Read More
Categories:
Farrukh Ali KhanStructural and functional characterisation of bacterial virulence factors
Structural and functional characterisation of bacterial virulence factors
About the Project In the current era of growing antibiotic resistance, the world needs new therapeutics against bacterial infections as well as new vaccines. The project will focus on the … Read More Read More
Categories:
Tiffany WilliamsMechanism of transcription-coupled splicing
Mechanism of transcription-coupled splicing
About the Project The production of messenger RNA in eukaryotic cells involves precursor mRNA (pre-mRNA) synthesis and processing. During splicing, the spliceosome removes noncoding introns from pre-mRNA in a co-transcriptional … Read More Read More
Categories:Pathological protein assembly in neurodegenerative diseases
Pathological protein assembly in neurodegenerative diseases
About the Project Neurodegenerative diseases are one of the greatest health challenges facing our society. This large group of diseases is characterised by the pathological assembly of specific proteins into … Read More Read More
Categories:Biochemical and structural studies of yeast telomerase complexes
Biochemical and structural studies of yeast telomerase complexes
About the Project The ends of linear eukaryotic chromosomes are typically composed of tandem G-rich repeats, which play a crucial role in attracting telomeric protein factors to assemble large nucleoprotein … Read More Read More
Categories: