Antonio SanchezAnalysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
About the Project Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to … Read More Read More
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Jim TaylorGene-based replacement therapy for hearing loss
Gene-based replacement therapy for hearing loss
About the Project Hearing loss is the most common sensory dysfunction in humans, and it is associated with social isolation and depression. Approximately 1 billion people in the world will … Read More Read More
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Rebecca ShepherdMechanisms underlying the effects of activated protein C (APC) in cardiac muscle
Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle
About the Project APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is … Read More Read More
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Raelyn MillerMolecular mechanisms of the increase in maximal aerobic capacity (VO2max) with regular exercise
Molecular mechanisms of the increase in maximal aerobic capacity (VO2max) with regular exercise
About the Project Performing regular exercise is crucial for good health and wellbeing, whereas failing to perform sufficient exercise increases the risk of diseases such as cardiovascular disease, type 2 … Read More Read More
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Katie PorterBiomechanical signalling in human heart disease
Biomechanical signalling in human heart disease
About the Project About the Project The human heart undergoes more than 2 billion beats throughout an individual's lifetime, with its rhythm precisely regulated by signalling events that continuously adapt … Read More Read More
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Isabell BakerSex differences in epicardial fat modulation of cardiac function
Sex differences in epicardial fat modulation of cardiac function
About the Project This project will aim to determine whether structural and physiological properties of epicardial adipose tissue are responsible for the sex differences in human myocardial function and cardiac … Read More Read More
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Luke McCoyPhD student in cardiac muscle function at the fiber and molecular
PhD student in cardiac muscle function at the fiber and molecular
About the Project The Institute of Physiology II, University of Muenster, Germany, is offering a position starting as soon as possible limited to 3 years. PhD Student (gn*) Salary according … Read More Read More
Categories:Oxytocin neuron activity in lactation
Oxytocin neuron activity in lactation
About the Project Pulsatile secretion of the hormone, oxytocin, is essential for milk delivery during suckling and its secretion from the posterior pituitary gland is triggered by coordinated bursts of … Read More Read More
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William MielcarekMolecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes
Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes
About the Project The heart’s pacemaker, the sinus node, initiates the action potential that causes the heart to beat, and the atrioventricular node conducts the action potential from the atria … Read More Read More
Categories:Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage
Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage
About the Project Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). … Read More Read More
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