Kirsten RogdeNovel Radiotracers and Radiochemical Methods for the Biomedical Technique of Positron Emission Tomography (PET)
Novel Radiotracers and Radiochemical Methods for the Biomedical Technique of Positron Emission Tomography (PET)
About the Project With strong alignment to the clinical programmes within the Department of Clinical Neurosciences and other departments in the Clinical School, our programme of research is the discovery … Read More Read More
Categories:Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
About the Project The project focuses on the intracellular stages of amyloidogenesis, aiming to unravel the complex mechanisms contributing to diseases such as Alzheimer's. Using ultrahigh-resolution live microscopy to monitor … Read More Read More
Categories:Inflammation in Frontotemporal Lobar Degeneration: A Multimodal Approach towards New Therapeutics
Inflammation in Frontotemporal Lobar Degeneration: A Multimodal Approach towards New Therapeutics
About the Project Neuroinflammation is an important driving mechanism in all diseases caused by frontotemporal lobar degeneration, and predicts clinical progression. Our research programme uses PET imaging and advanced blood … Read More Read More
Categories:Metabolic Control of Microglia in MS-Associated Cognitive Decline
Metabolic Control of Microglia in MS-Associated Cognitive Decline
About the Project Multiple sclerosis (MS) is a devastating neurological condition affecting millions worldwide. Cognitive impairment significantly impacts the quality of life of people with MS and is often irreversible. … Read More Read More
Categories:Neural Stem Cell – Niche Interactions in Mitochondrial Disease
Neural Stem Cell – Niche Interactions in Mitochondrial Disease
About the Project Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present … Read More Read More
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Rebecca ShepherdInvestigation of the extracellular matrix as a regulator of Parkinson’s progression
Investigation of the extracellular matrix as a regulator of Parkinson’s progression
About the Project Parkinson’s is the 2 nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is … Read More Read More
Categories:4-year PhD Studentship: The Role of Cell Fusion in Maintaining and Restoring Cerebellar Function
4-year PhD Studentship: The Role of Cell Fusion in Maintaining and Restoring Cerebellar Function
About the Project The cerebellum plays a critical role in control and coordination of movements in addition to higher-order functions including cognition and emotional processing. Diseases involving the cerebellum occur … Read More Read More
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Jim TaylorThe epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection
The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection
About the Project A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult … Read More Read More
Categories:Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
About the Project Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion … Read More Read More
Categories:New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
About the Project The imidazotetrazine ring system that forms the core of the anticancer drug temozolomide is a fascinating prodrug delivery device. The bicyclic structure bears only three substituents. These … Read More Read More
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