Kirsten RogdeNovel Radiotracers and Radiochemical Methods for the Biomedical Technique of Positron Emission Tomography (PET)
Novel Radiotracers and Radiochemical Methods for the Biomedical Technique of Positron Emission Tomography (PET)
About the Project With strong alignment to the clinical programmes within the Department of Clinical Neurosciences and other departments in the Clinical School, our programme of research is the discovery … Read More Read More
Categories:Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
About the Project The project focuses on the intracellular stages of amyloidogenesis, aiming to unravel the complex mechanisms contributing to diseases such as Alzheimer's. Using ultrahigh-resolution live microscopy to monitor … Read More Read More
Categories:Inflammation in Frontotemporal Lobar Degeneration: A Multimodal Approach towards New Therapeutics
Inflammation in Frontotemporal Lobar Degeneration: A Multimodal Approach towards New Therapeutics
About the Project Neuroinflammation is an important driving mechanism in all diseases caused by frontotemporal lobar degeneration, and predicts clinical progression. Our research programme uses PET imaging and advanced blood … Read More Read More
Categories:Metabolic Control of Microglia in MS-Associated Cognitive Decline
Metabolic Control of Microglia in MS-Associated Cognitive Decline
About the Project Multiple sclerosis (MS) is a devastating neurological condition affecting millions worldwide. Cognitive impairment significantly impacts the quality of life of people with MS and is often irreversible. … Read More Read More
Categories:Neural Stem Cell – Niche Interactions in Mitochondrial Disease
Neural Stem Cell – Niche Interactions in Mitochondrial Disease
About the Project Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present … Read More Read More
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Jim TaylorUsing microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
About the Project Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion … Read More Read More
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Rebecca Shepherd4-year PhD Studentship: Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
4-year PhD Studentship: Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
About the Project Parkinson’s disease is a progressive neurodegenerative disorder characterised by a wide range of motor and non-motor features, for which there is no known cause. There is large … Read More Read More
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Sergio DiazExploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts
About the Project Parkinson’s disease is a progressive neurodegenerative disorder characterised by a wide range of motor and non-motor features, for which there is no known cause. There is large … Read More Read More
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Zoe LartigauDeveloping a clinical pathway to support nurse led whole genome sequencing for neurological diseases
Developing a clinical pathway to support nurse led whole genome sequencing for neurological diseases
About the Project In this project we will develop pathways to enable specialist nurses to request whole genome sequencing (WGS) for adult neurology patients throughout the NHS; improving the efficiency … Read More Read More
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Miguel PereiraMicroplastics and Nanoplastics as Emerging Risk Factors in Neurodevelopmental and Neurodegenerative Condition
Microplastics and Nanoplastics as Emerging Risk Factors in Neurodevelopmental and Neurodegenerative Condition
About the Project Project Overview: Microplastics (MPs) and nanoplastics (NPs) are ubiquitous environmental pollutants raising concerns due to their potential adverse effects on human health. MPs/NPs accumulate in various tissues … Read More Read More
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